It is well known that DNA methylation and histone deacetylation both repress gene transcription. When histones are acetylated, their electrostatic interactions with DNA become weaker, resulting in relaxed chromatin, which upregulates transcription; the opposite happens when histones are deacetylated by HDAC.

Does methylation affect acetylation?

Methylation does not change the association of acetylated histones with adjacent unmethylated DNA.

How acetylation and methylation affects chromosome expression?

These modifications can control gene expression by altering chromatin structure. ... For instance, methylation of histones H3 and H4 regulates the activity of origins of DNA replication [22], while on the other hand, acetylation of histones affects chromatin structure and gene transcription [23].