Caffeine reduces collagen synthesis in human cultured skin fibroblasts. HA did not have any significant protective effect on this process. This is the first study to our knowledge that reports caffeine-induced inhibition of collagen synthesis in human skin fibroblasts.

Can I drink coffee while taking collagen?

Generally, collagen protein can be safely added to hot coffee, as brewing temperatures are usually below the point at which collagen proteins break down.

What interferes with collagen?

Sugar, in particular, can be tough on collagen. "High sugar levels can lead to hardening and fragmentation of collagen, weakening the skin foundation, and promoting premature skin aging," Zeichner says.