Granulocytes are produced in the bone marrow and released into the blood and tissues, where they act as the first line of defense in host resistance and wound healing (13). The total granulocyte pool is divided into two compartments: the bone marrow and the circulating pools.

How are granulocytes formed?

Granulocytes are derived from stem cells residing in the bone marrow. The differentiation of these stem cells from pluripotent hematopoietic stem cell into granulocytes is termed granulopoiesis. Multiple intermediate cell types exist in this differentiation process, including myeloblasts and promyelocytes.

Where does the granulocytes are formed?

Granulocytes are formed in the bone marrow and can be classified as basophils, eosinophils, mast cells, and neutrophils.