Capacitation regulates the ability of sperm reach the site of fertilization and to interact with eggs. As such, the underlying mechanisms are central to an understanding of mammalian fertilization.

What is capacitation and give its importance?

(1) Capacitation is the process by which the sperms are made capable to swim up to the fallopian tubes. ... (2) 50% of ejaculated sperms die due to unfavourable vaginal and uterine conditions. (3) The remaining sperms are capacitated with the help of prostaglandin and vestibular secretions of female tract.

Why capacitation of the sperm is necessary?

In order to fertilize, the spermatozoa of eutherian mammals must undergo capacitation in the female tract. The subcellular changes involved in capacitation finally seem to permit the influx of Ca2+ required for onset of the acrosome reaction, and they result also in a hyperactivated form of motility.