Diuretics can stop working and that doesn't mean anything bad necessarily. Different diuretics work on different parts of the kidney. If one stops working or doesn't work as well, your doctor can change up your medications to see if something else works better.

What happens when furosemide stops working?

What will happen if I come off it? Talk to your doctor if you want to stop taking furosemide. Stopping it may cause your blood pressure to rise - and this may increase your risk of heart attack and stroke. If you're bothered by side effects, your doctor may be able to prescribe you a different medicine.

How do you overcome diuretic resistance?

Strategies to overcome diuretic resistance include restriction of sodium intake, changes in dose, changes in timing, and combination diuretic therapy.