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Where Does Prothrombinase Come from?

Maya Lin-Takahashi • • 6 min read
Where Does Prothrombinase Come from?

Prothrombinase assembly begins with the binding of Factor Xa and Factor Va

Factor Va
Factor V (pronounced factor five) is a protein of the coagulation system, rarely referred to as proaccelerin or labile factor. In contrast to most other coagulation factors, it is not enzymatically active but functions as a cofactor.
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to negatively charged phospholipids on plasma membranes. Activated Factor Xa and Factor Va bind to the plasma membranes of a variety of different cell types, including monocytes, platelets, and endothelial cells.

Where is prothrombinase formed?

The substrate, prothrombin, is a circulating single-chain vitamin K–dependent zymogen produced by the liver. Within the prothrombinase complex, FXa cleaves prothrombin at 2 sites producing a two-chain (A and B) active protease, called α-thrombin, held together by a single disulfide bond.

Is prothrombinase formed in liver?

Prothrombin, a plasma protein valuable in blood coagulation, appears to be produced exclusively by liver parenchymal cells.

Maya Lin-Takahashi
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Maya Lin-Takahashi

Maya is a hardware enthusiast who tests and reviews smart home devices, smartphones, wearables, and audio gear. She focuses on practical consumer value and build quality.