For people with ventricular fibrillation: Digoxin can't be used if you have ventricular fibrillation. It may make your ventricular fibrillation worse. For people with Wolff-Parkinson-White syndrome: If you have Wolff-Parkinson-White syndrome, you're at a higher risk for an abnormal heart rhythm.

When should you not give digoxin?

A beta-blocker or calcium antagonist (either alone or in combination with digoxin) is indicated when digoxin is ineffective for ventricular rate control. Digoxin is ineffective in restoring sinus rhythm, preventing paroxysms or controlling rate in paroxysmal AF. The elderly are at an increased risk of digoxin toxicity.

When should you not give digoxin heart rate?

If your pulse becomes fast, irregular, or a pulse below 60 beats per minute. Chest pain, or pain that goes to the shoulder, neck, or jaw. Bloody or black stools. Drowsiness or confusion.