I'm facing a problem with this scenario using latest versions of:

• VirtualBox: Version 6.1.6 r137129 (Qt5.6.2)
• Host: Windows 10 Home (Version 19035.1) (virtualization is enabled in the BIOS and Hyper-V is not installed as it's Windows 10 Home Edition)
• Client: Windows Server 2019 (Version 19624)

As soon as I run the VM for installation from ISO file VirtualBox says:

A critical error has occurred while running the virtual machine and the machine execution has been stopped.

For help, please see the Community section on or your support contract. Please provide the contents of the log file VBox.log and the image file VBox.png, which you can find in the C:\Users\franc\VirtualBox VMs\Windows Server_\Logs directory, as well as a description of what you were doing when this error happened. Note that you can also access the above files by selecting Show Log from the Machine menu of the main VirtualBox window.

Press OK if you want to power off the machine or press Ignore if you want to leave it as is for debugging. Please note that debugging requires special knowledge and tools, so is recommended to press OK now.

I allocated to the VM:

• 2 CPUs
• 80GB of Virtual HD
• 4096MB or RAM (I also tried to allocate 2048MB, same error)
• Chipset: PIIX3
• Enable I/O APIC
• Enable PAE/NX

In the logs VBox.log I see:

00:00:03.357707 ERROR [COM]: aRC=VBOX_E_VM_ERROR (0x80bb0003) aIID={4680b2de-8690-11e9-b83d-5719e53cf1de} aComponent={DisplayWrap} aText={Could not take a screenshot (VERR_NOT_SUPPORTED)}, preserve=false aResultDetail=-37

and:

00:00:12.148500 VCPU[0] APIC Local Vector Table (LVT):
00:00:12.148501 lvt     timermode  mask  trigger  rirr  polarity  dlvr_st  dlvr_mode   vector
00:00:12.148502 Timer    One-shot   1                               Idle                 0 (0x0)
00:00:12.148507 Thermal             1                               Idle     Fixed       0 (0x0)
00:00:12.148511 Perf                1                               Idle     Fixed       0 (0x0)
00:00:12.148514 LINT0               0     Edge      0   ActiveHi    Idle     ExtINT      0 (0x0)
00:00:12.148517 LINT1               0     Edge      0   ActiveHi    Idle     NMI         0 (0x0)
00:00:12.148541 Error               1                               Idle     Fixed       0 (0x0)
00:00:12.148545 VCPU[1] APIC Local Vector Table (LVT):
00:00:12.148546 lvt     timermode  mask  trigger  rirr  polarity  dlvr_st  dlvr_mode   vector
00:00:12.148547 Timer    One-shot   1                               Idle                 0 (0x0)
00:00:12.148549 Thermal             1                               Idle     Fixed       0 (0x0)
00:00:12.148552 Perf                1                               Idle     Fixed       0 (0x0)
00:00:12.148554 LINT0               1     Edge      0   ActiveHi    Idle     Fixed       0 (0x0)
00:00:12.148556 LINT1               1     Edge      0   ActiveHi    Idle     Fixed       0 (0x0)
00:00:12.148558 Error               1                               Idle     Fixed       0 (0x0)

While in VBoxHardening.log:

42e4.2024: supR3HardenedMonitor_LdrLoadDll: error opening 'C:\Windows\System32\edgegdi.dll': 0 (NtPath=\??\C:\Windows\System32\edgegdi.dll; Input=edgegdi.dll; rcNtGetDll=0xc0000135

and:

42e4.2024: supR3HardenedMonitor_LdrLoadDll: error opening 'C:\Windows\system32\wintab32.dll': 0 (NtPath=\??\C:\Windows\system32\wintab32.dll; Input=C:\Windows\system32\wintab32.dll; rcNtGetDll=0x0

..and, yes, Windows Defender is OFF.