Keanu Reeves has proven himself a tireless advocate for a "Constantine" sequel, fighting the good fight since 2005. "I kept asking almost every year," he told Total Film (via MovieWeb) of his personal lobbying of Warner Bros. executives. In 2021, he spoke about the character to Esquire, effusing, "I love playing Constantine. ... I'd love to have the chance to play Constantine again." And when Stephen Colbert asked Reeves about the possibility of a sequel on "The Late Show," the actor sadly responded, "I've tried. I've tried."

Reeves isn't the only actor who's considered showing up for part two. Peter Stormare, who portrayed Lucifer in the original "Constantine," told ScreenRant in 2022 that discussions about a sequel began within a year after the first film's 2005 release and that interest from producers gradually increased. "The DVD sold pretty good, and social media started to come around, and 'Constantine' was always something that people did love." 

Stormare also said that sequel talks grew especially promising around 2007, 2009, and 2011 without production ever officially beginning. The Lucifer actor shared that Reeves was a principal agitator, urging producers to not wait too long. "If we have the same director, the same writer, the same cast, we might be able to pull it off," Stormare hypothesized. "That's the problem of doing 'Constantine 2,' this might be too late."

In April 2023, Rachel Weisz — who played twins Isabel and Angela Dawson — discussed the possibility of another film, but her involvement doesn't seem likely. "No, I haven't heard anything about it," she told ComicBook.com.