Roger Pirates

Gol D. Roger: The Pirate King referred to Rayleigh as his "partner" because of their close bond. Rayleigh could not bear to watch his best friend be put to death after the man surrendered to the Marines.

Buggy and Shanks: They frequently argued with each other while serving as apprentice pirates on the ship, which led to Rayleigh punishing them. Despite this, Buggy still holds the former first mate of the crew in high regard. After Shanks and Rayleigh's reunion at the Sabaody Archipelago, Rayleigh expressed interest in meeting Luffy after Shanks informed him about a youngster he met in East Blue.

Crocus: Despite the doctor's limited stay with them, Rayleigh expressed appreciation for him as a crewmate and his wish to work with him again.

Kozuki Oden: He respected Oden greatly, just like the rest of the crew. Oden rejected Rayleigh's offer to assist him in opening Wano Country to the outside world.

Shakuyaku

Rayleigh's wife and business partner is Shakuyaku. She has Rayleigh's complete trust, and he knows her strengths. Rayleigh used her calculations to track down Luffy after the war.

Friends

Monkey D. Luffy: Rayleigh had been eager to meet Luffy since he first learned about him from Shanks. In light of Luffy's statement that the Pirate King enjoys the greatest freedom on the sea, he shares Shakky's high expectations for him. Luffy received instruction from Rayleigh on how to master each of the three Haki variants. It is clear from the two-year time gap that they grew close during their training. Rayleigh was left with a smile and tears in his eyes as Luffy shouted to him as he made his way towards Thousand Sunny that he would soon become the Pirate King.

Boa Hancock: Rayleigh is the only male individual besides Luffy allowed to enter Amazon Lily. He and Shakuyaku went to Amazon Lily to aid the Kuja after the Seven Warlords of the Sea were abolished. He ran into Blackbeard, who attacked the island and made a deal with him and the Marines for Hancock to reverse her devil fruit effect and then everyone left, saving both Hancock and Amazon Lily.

Straw Hat Pirates: Rayleigh helped the Straw Hat Pirates numerous times after first encountering them at the Human Auctioning House event. He provided free coating for the Thousand Sunny and protected the crew from Kizaru. When the Marines hunted the crew two years after the Summit War of Marineford, Rayleigh assisted the Straw Hats in escaping.

Hatchan: Silvers Rayleigh and Hatchan are buddies because the former saved the latter from a shipwreck when they were kids. Since then, the two have maintained strong relations; nonetheless, Rayleigh disagreed with Hatchan joining Fisher Tiger's Sun Pirates.

Jinbe: Additionally, it appears that Jinbe, the former Warlord of the Sea, and Rayleigh have grown close. He participated in the ringing of the Ox Bell, the circling of Marineford, and the theft of a Marine ship.

Gloriosa: Rayleigh and Shakky are good friends with Gloriosa, and Rayleigh is one of the few, if not the only, to call her by her given name. Gloriosa stayed on Sabaody Archipelago with Rayleigh and Shakky while sheltering the Gorgon Sisters following their run-in with the World Nobles before returning to Amazon Lily.

Enemies

World Government: Rayleigh is among few of those to know the world's true history. Such individuals are viewed as a serious threat by the government.

Marines: Rayleigh and the other Roger Pirates have already run into several Marines, namely Monkey D. Garp. He was a powerful enemy of the Marines due to his affiliation with one of the most formidable pirate crews.

Edward Newgate: Rayleigh had a rivalry with the Whitebeard Pirates as a member of the Roger Pirates. Nevertheless, Rayleigh holds Edward Newgate in high regard, much like he does his captain.

Blackbeard: Rayleigh had some respect for Whitebeard's crew even though they were rivals, and Teach was the only person on that crew whom Rayleigh hated. This hate would intensify due to Blackbeard's killing of his former captain, theft of Whitebeard's abilities, and claiming of his domains. He continues to make Rayleigh despise him with his abusive acts. Rayleigh refers to Blackbeard as "Whitebeard's Cabin Boy."

Chinjao: When Luffy revealed that Rayleigh taught him how to handle Haki, Chinjao expressed his dismay at learning that the Pirate King's right hand is still alive, suggesting that Chinjao may hold resentment towards Rayleigh.