In 2012 Peter Molyneux works at the independent game development studio 22 Cans. It was founded by Tim Rance who previously worked at Lionhead Studios, established by Molyneux in August 1997. He announced to leave Lionhead in March 2012 after having led the company for almost fifteen years. After it was acquired by Microsoft in 2006 it is best known for its Fable series.

Previously Molyneux co-founded Bullfrog Productions in 1987 with Les Edgar where he was responsible for acclaimed projects such as the Populous series, the Theme Park series, the Magic Carpet series and the Syndicate series.