Alien Infestation is a third-person shooter set in a dark future. The player is a marine armed with guns who must fight against zombies and aliens in a futuristic, abandoned city. The story in the game is presented through comic-style cut-scenes. Opponents usually appear in large numbers, but the marine has unlimited ammo. Controls are limited to moving around, aiming and shooting. There are three difficulty modes. Next to the third-person view, first-person is also available.