On television, Detmer was regular cast member on the two short-lived NBC sitcoms, M.Y.O.B. (2000) starring Lauren Graham, and A.U.S.A. (2003) opposite Scott Foley. From 2006 to 2007, she starred in the ABC comedy-drama What About Brian alongside Barry Watson, Sarah Lancaster and Rosanna Arquette. In 2009, she had a recurring role in the ABC medical drama Private Practice. From 2011 to 2012, she co-starred in the another ABC series, short-lived sitcom Man Up!. From 2011 to 2013, Detmer also had a recurring role in the USA Network drama series Necessary Roughness. She also guest starred on Law & Order: Criminal Intent, The Vampire Diaries, The Mentalist, and Two and a Half Men. In 2017, Detmer was cast in the untitled drama starring Reba McEntire for ABC, created by Marc Cherry.