Murray finished shooting Possessions in 2010 and soon thereafter began shooting The Rapture. She starred in the horror film Devil's Playground(2010), directed by Mark McQueen, and then appeared as Helena G. Wells on the Syfy series Warehouse 13. Murray's portrayal of Helena G. Wells received critical praise. Her portrayal was described as "saucy", "superb", as able to "anchor a series", and "endlessly fascinating". Her absence as the villainess in the season 3 Christmas episode, "The Greatest Gift", was bemoaned with the lamentation "she would have done it better". Murray was nominated for a 2012 Portal Award for her portrayal of Helena G. Wells on Warehouse 13.