In 2014, Clayton was cast as one of leads in the Oprah Winfrey Network series If Loving You Is Wrong. Later that year, she was cast opposite Miles Teller and Katey Sagal in the biographical drama film Bleed For This about boxer, Vinny Pazienza. In addition to Bleed For This, Clayton is the female lead in two additional feature-length films set for release in 2016, the comedy, The Bet and the drama, Bad Frank. In 2017, she played the leading role in the Lifetime Movie Cradle Swapping.