Josephus Lyles is an American sprinter. He completed his high school at T. C. Williams High School in Alexandria, Virginia. He mainly takes part in 200 and 400-meter run. He had planned to try out for the basketball, but his brother Noah pulled him to the track.

In 2016, Josephus suffered from a season-ending torn right hip flexor two months before the Olympic Trials. In July 2016, Josephus and his brother Noah turned professional and signed an eight-year contract with Adidas. They left the classes at the University of Florida and ran after their dream as a pro sprinter. At the 2018 USATF Outdoors, Noah won the 100m, and Josephus placed sixth in the 400m.