The availability of drugs such as the bisphosphonates and calcitonin that inhibit bone resorption, which is primarily responsible for the hypercalcemia.

Do bisphosphonates cause hypocalcemia?

By inhibiting bone resorption, bisphosphonates reduce calcium efflux from bone into the circulation, leading to the development of hypocalcemia.

How do bisphosphonates work in hypercalcemia?

Bisphosphonates inhibit osteoclastic bone resorption and are effective in the treatment of hypercalcemia due to conditions causing increased bone resorption and malignancy-related hypercalcemia. Pamidronate and etidronate can be given intravenously, while risedronate and alendronate may be effective as oral therapy.