Did Sasuke Really Kill Itachi? Sasuke didn't really kill Itachi in a traditional sense. Itachi intended to die during their fight, helping Sasuke to become a hero in the village and gain new power while restoring the clan.

Who actually killed Itachi?

In 2009, Itachi died in the anime after a climactic battle with Sasuke, wherein he gives Sasuke his Sharingan power. Having been wracked by guilt, Itachi had always known that the only way he could meet his end was by Sasuke's hand.

Did Itachi die from disease or Sasuke?

Even though Itachi was suffering from a mysterious respiratory disease, he died while fighting the person he loved the most.