Prions are infectious particles that contain no nucleic acids, and viroids are small plant pathogens that do not encode proteins.

Are viroids and prions microbes?

Viroids consist of small, naked ssRNAs that cause diseases in plants. Virusoids are ssRNAs that require other helper viruses to establish an infection. Prions are proteinaceous infectious particles that cause transmissible spongiform encephalopathies. Prions are extremely resistant to chemicals, heat, and radiation.

Are prions and viroids living?

Viruses, prions and viroids are non-living organisms that require a living cellular host in order to reproduce. They cannot do it on their own. These parasites may be just a string of RNA, as in a viroid, or a length of DNA enclosed in a protein shell, as in a virus.