Uncompetitive inhibitors bind only to the enzyme-substrate complex and not to the free enzyme. Substrate-binding could cause a conformational change to take place in the enzyme and reveal an inhibitor binding site (Fig. 8.3c), or the inhibitor could bind directly to the enzyme-bound substrate.

What do uncompetitive inhibitors bind to?

Uncompetitive inhibition occurs when an inhibitor binds to an allosteric site of a enzyme, but only when the substrate is already bound to the active site. In other words, an uncompetitive inhibitor can only bind to the enzyme-substrate complex.

Where do noncompetitive inhibitors bind quizlet?

A non-competitive inhibitor binds in two places: either on the enzyme or on the enzyme-substrate complex. It's important to note that it does not bind to the active site.