Clonal deletion is the removal through apoptosis of B cells and T cells that have expressed receptors for self before developing into fully immunocompetent lymphocytes. This prevents recognition and destruction of self host cells, making it a type of negative selection or central tolerance.

What is clonal deletion quizlet?

clonal deletion is? Process by which B cells and T cells are deactivated after have expressed receptors for self-antigens and before they develop into fully imunocompetent lymphocytes. clonal anergy is? Immature B cells that bind solube self-antigen are not deleted, but become anergic. You just studied 37 terms!

How is clonal deletion related to autoimmune disease?

Clonal deletion reliably removes all T cells that can mount aggressive responses against self MHC molecules; the organ-specific autoimmune diseases, which involve rare T-cell responses to a particular self peptide bound to a self MHC molecule, are therefore unlikely to reflect a general failure in clonal deletion; nor ...