Like other antidepressants, SSRis — including Zoloft (sertraline), Celexa (citalopram, Prozac (fluoxetine) and others — can cause certain side effects, including weight gain. In fact, some studies have shown that the more often you use them, the more weight you may gain.

Can sertraline cause weight loss?

Sertraline can make you feel more or less hungry than usual, so you may lose or gain weight when you start taking it. If you start to have problems with your weight while taking sertraline, talk to your doctor or pharmacist.

What is the best antidepressant for weight loss?

Of these three medications, bupropion (Wellbutrin) is the most consistently associated with weight loss. Several studies, including a 2019 meta-analysis of 27 studies, found that bupropion (Wellbutrin) was the only commonly used antidepressant associated with weight loss.