Calamine is an anti-itch medicine that works by causing a cooling sensation as it evaporates on your skin. Calamine also dries oozing or weeping from minor skin irritation.

What does calamine lotion do to the body?

Calamine lotion is a widely available OTC topical medication that can help relieve itching caused by minor skin irritations. It can also help dry out oozing and weeping from reactions to poisonous plants, such as poison oak, poison ivy, or poison sumac. Calamine lotion isn't a cure, but it can help relieve symptoms.

Can I leave calamine lotion on overnight?

Calamine lotion can dry up acne lesions and may be left on overnight as a spot treatment. Use over the entire face is not recommended as it can cause dryness and sensitivity.