Malady will teleport away if the player tries to kill her on Reaper's Eye island. If the player kills her in 1 hit, they will not be able to leave the island and proceed to the next Act.
Can you save malady?
Save Malady
Malady will transport the entire ship to the Hall of Echoes after around four or so turns complete. This means this strategy can be completed by stalling, avoiding damage, and healing. Place buffs on Malady like Armor of Frost, Fortify, Uncanny Evasion, and Living on the Edge as needed.
Can I romance malady?
5 CAN'T: Malady
This particular character is with the player throughout the entire game yet they can't romance her!