The Wraith attacked Atlantis with their powerful weapons, but the Ancients' shield held. Defeated, the Ancients decided to submerge the city and leave through the Stargate to Earth. ... Their regenerative abilities are so powerful that it is unlikely that the Wraith ever die from natural causes the way that humans do.

What was the Wraith weakness?

Silver - Wraiths have a great weakness to silver; silver burns their skin, being stabbed in the heart by a silver blade will kill them.

Did the Ancients create the Wraith?

The Ancients in the Pegasus Galaxy from the city-ship Atlantis seeded the galaxy with humanity and unwittingly created their future rival, the Wraith. The Wraith were the result of the blending of the DNA of the iratus bug and humans.