People use indole-3-carbinol for cancer prevention, to treat systemic lupus erythematosus (SLE), and for many other conditions, but there is no good scientific evidence to support these uses.

Does indole-3-carbinol help with weight loss?

Indole-3-carbinol prevents diet-induced obesity through modulation of multiple genes related to adipogenesis, thermogenesis or inflammation in the visceral adipose tissue of mice. J Nutr Biochem.

Does indole-3-carbinol increase estrogen?

Whereas estrogen increases the growth and survival of tumors, I3C causes growth arrest and increased apoptosis and ameliorates the effects of estrogen.