Exhaustion and sleep loss can have plenty of consequences, but it's pretty rare to die from lack of sleep. That said, operating on little to no sleep can increase your risk of having an accident while driving or doing something potentially hazardous.

Can fatigue can kill you?

Why myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) may kill you: disorders in the inflammatory and oxidative and nitrosative stress (IO&NS) pathways may explain cardiovascular disorders in ME/CFS. Neuro Endocrinol Lett.

Can fatigue be life threatening?

Serious symptoms that might indicate a life-threatening condition. In some cases, fatigue can indicate a serious or life-threatening condition, such as acute heart failure or gastrointestinal bleeding, which should be immediately evaluated in an emergency setting.