History. The first Primes originated from a group of colonists, Mission Team Alpha, who are also referred to as the Primes. They colonized Sanctum and became the ruling family through the bodies of the Nightblood hosts.

Is Murphy a prime the 100?

Technically, Murphy is currently a Prime, so, if he's your favorite character and he does die...

What are the people from Sanctum?

The citizens of Sanctum, known as the Sanctumites, are the descendants of the embryos brought from Earth by Mission Team Alpha.