Disadvantage doesn't stack. One or more instances of advantage cancels out one or more instances of disadvantage resulting in a flat roll. All of that being said, double advantage or double disadvantage can be a fun house rule when you want to REALLY skew the odds or something happening.

Does advantage cancel disadvantage DND 5e?

Advantage and disadvantage cancel each other regardless of the number of things that give either of them to you. Either you have advantage/disadvantage or you don't. Instances of them don't stack up.

Is there double disadvantage?

For decades social scientists described how being both foreign-born and female was a “double disadvantage” on a person's likelihood to have a job in the United States. New Vanderbilt research shows that where you're born doesn't matter nearly as much as whether you're married and a woman.