Everyone has two copies of the BRCA1 and BRCA2 genes, one copy inherited from their mother and one from their father. Even if a person inherits a BRCA1 or BRCA2 mutation from one parent, they still have the normal copy of the BRCA1 or BRCA2 gene from the other parent.

Where did the BRCA1 gene originate?

The founder mutation BRCA1 c. 211A>G, that leads to aberrant splicing of the transcript, originates from North Western Spain (Galicia) and accounts up to 50% of all mutations in this region [81]. It was also found in French and British families of Spanish origin [82].

Is the BRCA gene passed through father?

BRCA mutations can be a family matter

Everyone carries 2 copies of BRCA genes inherited from his or her mother and father. If 1 parent has a BRCA mutation, all of his or her children have a 50% chance of inheriting that mutation.