Titin as a stabilizer of sarcomeres and half-sarcomeres. ... The half-sarcomere is unstable because small differences in half-sarcomere forces, caused by the stochastic interaction of cross-bridges with actin, will cause an initially centered myosin filament to be displaced from its mid-point position in the sarcomere.

What is the role of titin in the sarcomere?

Titin has long been recognized as a mechanical protein in muscle cells that has a main function as a molecular spring in the contractile units, the sarcomeres. Recent work suggests that the titin spring contributes to muscle contraction in a more active manner than previously thought.

What is the function of titin?

A primary function of titin is giving elastic stabilization of relative positions of myosin and actin filaments. It has regions that mirror the different parts of the sacromere, which have mechanical functions, catalytic functions and the ability to bind many other sacromere proteins.