Primary aldosteronism occurs when the adrenal gland produces excessive aldosterone without being stimulated by renin. Aldosterone causes sodium retention in the kidney in exchange for potassium and hydrogen ions. The result is the triple harms of hypertension, hypokalemia, and metabolic acidosis, explained Dr.

Does aldosterone cause acidosis?

Pharmacological blockade of aldosterone action as well as inherited or acquired syndromes of impaired aldosterone release or action impair the renal response to acid loading and cause hyperkalemic renal tubular acidosis.

Does hyperaldosteronism cause acidosis or alkalosis?

Hypersecretion of aldosterone is generally considered to be the proximate cause of metabolic alkalosis in primary aldosteronism and has also been invoked as an important factor in the genesis and maintenance of alkalosis in the postoperative patient.