High-dose Cyclophosphamide Physician-scientists at Johns Hopkins developed a treatment using high doses of the chemotherapy drug cyclophosphamide, without bone marrow transplantation, to achieve long-lasting, complete remissions in some patients with severe aplastic anemia.

Is aplastic anemia a form of cancer?

Although aplastic anaemia is not a malignant disease (cancer) it can be very serious, especially if the bone marrow is severely affected and there are very few blood cells left in circulation.

Is aplastic anemia a terminal illness?

Aplastic anemia is a life-threatening condition with very high death rates (about 70% within 1 year) if untreated. The overall five-year survival rate is about 80% for patients under age 20.