We then analyzed the influence of exercise training against the side effects of cisplatin, such as cachexia and nephrotoxicity. As depicted in Figure 1C, we observed that aerobic exercise could attenuate cisplatin-induced body weight loss, the most prominent symptom of cachexia.

How do you manage cisplatin induced nephrotoxicity?

Active hydration with saline and simultaneous administration of mannitol before, during and after cisplatin treatment, significantly reduce cisplatin nephrotoxicity and this strategy has been accepted as the standard of care for reducing the associated side effects53).

Does cisplatin cause nephrotoxicity?

Cisplatin is a widely used and highly effective cancer chemotherapeutic agent. One of the limiting side effects of cisplatin use is nephrotoxicity. Research over the past 10 years has uncovered many of the cellular mechanisms which underlie cisplatin-induced renal cell death.