Base analogs are derivatives of the normal DNA bases, which may mimic to varying extents the properties of the normal bases. As such, they have the ability to interfere with normal nucleotide metabolism and exert a variety of toxic and mutagenic effects.

What are base analogs in genetics?

Base analogues are molecules that can substitute for normal bases in nucleic acids. Usually, substitution of a base analogue will result in altered base pairings and structural changes that affect DNA replication and transcription of genes.

What is the role of base analog in mutation?

Base analog mutagens are chemicals that mimic bases to such an extent that they can be incorporated into DNA in place of one of the normal bases but in doing so lead to an increase in the rate of mutation. To be mutagenic, a base analog must mispair more frequently than the normal base it replaced.