Just how much does an EpiPen hurt? Like other injections that go into the muscle (e.g. B12 injections or vaccinations), there's a sharp sting as the needle punctures the skin. Then there's a deep ache as the medicine is released into the muscle. The sharp sting will hurt but lasts less than 10 seconds.

What does an EpiPen feel like?

Fast/pounding heartbeat, nervousness, sweating, nausea, vomiting, trouble breathing, headache, dizziness, anxiety, shakiness, or pale skin may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

Do epinephrine shots hurt?

Like many drugs, there might be side effects from epinephrine, such as anxiety, dizziness, and sweating, and swelling, pain, or changes in skin color at the injection site because of decreased blood flow to the area. And though rare, people with heart disease might experience chest pain after an injection.