Dissolution testing is an important tool for characterizing the performance of oral solid dosage forms. Its significance is based on the fact that for a drug to be effective, it must first be released from the product and dissolve in the gastrointestinal fluids before absorption into the bloodstream can happen.

How dissolution affect bioavailability?

For drugs belonging to Class II of pharmaceutical classification, the absorption process is limited by drug dissolution rate in gastrointestinal media. Therefore, enhancement of the dissolution rate of these drugs will present improved bioavailability. ... Each of these process leads to improved bioavailability.

What is pharmaceutical importance dissolution and disintegration testing?

Why do we do it? Like dissolution testing, Disintegration is often a pharmacopoeial testing requirement for the vast majority of solid dosage forms. It provides critical safety data on drug bioavailability in the body without having to utilise in vivo methods.