Pemphigus vulgaris occurs when the immune system mistakenly makes antibodies against proteins in healthy skin and mucous membranes. The antibodies break down the bonds between the cells, and fluid collects between the layers of the skin. This leads to blisters and erosions on the skin.

Does pemphigus ever go away?

In some cases, pemphigus vulgaris will go away once the trigger is removed. The condition causes the immune system to fight against the body's own cells in the same way that it fights off invading germs. With pemphigus vulgaris, the immune system looks for proteins that bind the cells of the skin.

Does pemphigus have sudden onset?

When someone develops pemphigus, it can develop slowly, causing blisters in the same area for years. Signs and symptoms can also show up quickly. Blisters can appear suddenly and spread. Widespread pemphigus can be life threatening.