This unexpected result likely originates from the conformational change of actin subunits at the barbed end, induced by cofilin side-binding. ... In these conditions, actin filament barbed ends thus exhibit a form of dynamic instability.

Are actin filaments dynamically unstable?

ABSTRACT. In cells, actin filaments continuously assemble and disassemble while maintaining an apparently constant network structure. This suggests a perfect balance between dynamic processes. Such behavior, operating far out of equilibrium by the hydrolysis of ATP, is called a dynamic steady state.

Are actin filaments dynamic?

Within cells, the actin cytoskeleton is dynamic, with filaments able to grow and shrink rapidly. Polymerization of G-actin in vitro is marked by a lag period during which nucleation occurs.