The hippocampus is critical for spatial navigation and processing of new information. It is the main brain region used to study long-term potentiation (LTP), a cellular mechanism of learning and memory. ... At P12, the TBS reliably induced enduring LTP lasting more than 3 hours (L-LTP).

How is LTP achieved?

LTP can be induced either by strong tetanic stimulation of a single pathway to a synapse, or cooperatively via the weaker stimulation of many. When one pathway into a synapse is stimulated weakly, it produces insufficient postsynaptic depolarization to induce LTP.

What does LTP do in the brain?

Long-term potentiation, or LTP, is a process by which synaptic connections between neurons become stronger with frequent activation. LTP is thought to be a way in which the brain changes in response to experience, and thus may be an mechanism underlying learning and memory.