Both TB and sarcoidosis are granulomatous diseases; TB is characterized by caseating granulomas, whereas sarcoidosis is characterized by noncaseating granulomas.

Are TB granulomas Caseating?

The granulomas of tuberculosis tend to contain necrosis ("caseating tubercules"), but non-necrotizing granulomas may also be present. Multinucleated giant cells with nuclei arranged like a horseshoe (Langhans giant cell) and foreign body giant cells are often present, but are not specific for tuberculosis.

Is TB Caseous?

The caseous necrosis is the basic process of tuberculosis disease in humans. The interval from infection to tuberculin conversion is never more than 8 weeks and in general is 5 to 7 weeks (21). The onset of caseous necrosis coincides with the development of acquired immune resistance or CMI and DTH.