When taken by mouth: SAMe is LIKELY SAFE It can sometimes cause gas, diarrhea, constipation, dry mouth, headache, insomnia, anorexia, sweating, dizziness, and nervousness, especially at higher doses. It can also make some people with depression feel anxious.

What are the side effects of Sam-E?

Side effects.

SAM-e seems to be a relatively safe drug. High doses of oral SAM-e can cause symptoms like gas, upset stomach, diarrhea, constipation, dry mouth, headache, dizziness, anxiety, and skin rashes. SAM-e can also trigger an allergic reaction in some people.

How does Sam-E affect mood?

Side Effects

Like any other activating anti-depressant, SAM-e can worsen underlying agitation, panic, or anxiety. Accompanying use of a mood stabilizer is essential if there is any indication of mania or bipolar disorder.