The epithelial tree of the developing salivary glands is initially formed by solid chords of epithelial cells. At approximately the 10th fetal week, these solid chords of epithelial cells start to be hollowed out to develop a lumen through which the future secretory products will be led to the oral cavity20.

When do salivary glands develop?

The salivary glands arise only in the later embryonic period (stage 18, ca. 44 days, 18 ). The first sign is a thickening of the epithelium on the side of the tongue, outside the anlage of the dental arch (lamina dentalis).

Where do salivary glands come from?

The parotid glands are the largest salivary glands. They are located just in front of the ears. The saliva produced in these glands is secreted into the mouth from a duct near your upper second molar. Each parotid gland has two parts, or lobes: the superficial lobe and the deep lobe.