not really. because the weight is near the axle is not as pronounced as in a wheel rim. However lighter is lighter and these days a good place to shave grams and the expense of dollars. I will say XX1 cassettes are a work of art.

Which cassette ratio is best for climbing?

For hill climbing and mountainous terrain, we recommend a road cassette such as the 11-32T SRAM Red 22 XG1190 11 Speed Cassette (A2), or the 11-34T Shimano Ultegra R8000 11 Speed Cassette.

How much does weight matter in cycling?

Additional weight increases inertia and wheel inertia matters a lot in cycling because the rider has to overcome it to accelerate. Heavier wheels require more energy to overcome this inertia. Many riders, even novices, can actually feel the difference when riding lighter wheels.