Splitting unscored tablets is considered “off-label” because each split tablet dose may not have equal drug strength. However, splitting drugs with a long half-life and wide therapeutic index—such as those used to treat chronic asymptomatic conditions like hypertension or dyslipidemia—should pose minimal risk.

Can you cut olmesartan in half?

This drug may be taken with or without food. You can crush or cut the tablet.

Can I cut rosuvastatin in half?

Do not crush, split, or otherwise break Crestor tablets before swallowing. Study Shows Patients Who Split Pills May End Up With Doses That Are Too High or Too Low. To get the best results from medicine, a perfect dosage is most important.