Nitrate-containing compounds have been identified as common headache triggers. Food preservatives are frequently identified triggers for those who suffer from migraines (1). Also, cardiac medications containing nitrates may cause severe headaches, which occur in over 80% of patients taking them.

Do nitrates or nitrites cause migraines?

Food preservatives, such nitrates and nitrites, found in processed meats might trigger migraines. Such additives can be found in hot dogs, ham, sausage, bacon and lunch meats, experts say.

Why do nitrates cause headaches?

The most frequently encountered side effect of nitrates is headache, which may be linked to vasodilation of the cerebral arteries due to direct activation of the nitric oxide-cyclic guanosine monophosphate pathway [8]. There exists an inverse relationship between nitrate response and atherosclerosis.