Results: Estrogen replacement therapy improved sleep quality, facilitated falling asleep, and decreased nocturnal restlessness and awakenings (p < 0.001). The subjects were less tired in the mornings and in the daytime (p < 0.001) when taking estrogen replacement therapy.

Does estradiol help with sleep?

For women with menopause-associated depression, improvement in depression is predicted by improved sleep, and among perimenopausal women, by increasing estradiol levels. These results suggest that changes in estradiol and sleep quality, rather than hot flashes, mediate depression during the menopause transition.

Does estrogen cream help you sleep?

"When we look at studies of estrogen on sleep in menopausal women, estrogen usually improves the quality of sleep, reduces time to fall asleep, and increases the amount of REM sleep. Sleep lab studies also indicate estrogen reduces the number of times a patient awakens and may improve cognitive function," says Trupin.