Both Excedrin^® and TYLENOL^® temporarily relieve minor aches and pains. TYLENOL^®, which contains acetaminophen, can be a more appropriate option for those with stomach problems than Excedrin^®, which contains a combination of the active ingredients, acetaminophen, aspirin and caffeine.

Is Excedrin similar to Tylenol?

Clinical studies have demonstrated that Excedrin Extra Strength relieves headaches better than Tylenol^® Extra Strength. Both Excedrin Extra Strength and Tylenol^® Extra Strength include acetaminophen, an analgesic that relieves pain and reduces fever.

Is Excedrin Tylenol or ibuprofen?

One of the key differences between Advil and Excedrin Migraine is that Excedrin is a combination medicine with three ingredients: 250 mg acetaminophen, commonly known by the brand name Tylenol. 250 mg aspirin, an NSAID like ibuprofen. 65 mg caffeine.