In the study by Yoshikawa et al., initiation and long-term PPI use was associated with at least a 5% weight gain in 36% of patients using PPIs compared to only 4% of patients who were not using a PPI over a two-year period of follow-up [5].

Can omeprazole make you gain weight?

Weight gain: Long-term use of omeprazole increases the risk of weight gain in patients with GERD.

Does acid reflux medicine make you gain weight?

Yes, Nexium and other heartburn drugs may cause weight gain — as can other drugs, such as certain antidepressants, beta-blockers, and antihistamines. You should talk to your doctor or pharmacist before starting any medication so you understand all the potential side effects of any drug you take.