After several discussions, it never happened—here's why. The 2009 sci-fi horror movie, Splice, left the perfect opening for a sequel, but despite seeming somewhat interested in continuing the story, director Vincenzo Natali never brought the project to fruition.

Is Splice based on a true story?

Vincenzo Natali, the director of the 2009 sci-fi horror movie, Splice, took inspiration for his creature, Dren, and the film's overarching plot from a real science experiment that's almost as strange as the film.

Is Elsa pregnant in Splice?

After Clive dies trying to save his partner, Elsa kills Dren once and for all, and is eventually shown to be carrying its child in Splice's epilogue. Rather than terminate the pregnancy, Elsa takes a healthy sum from her employer, Newstead Pharmaceuticals, to keep the child; as Dren's DNA is rich in scientific wonders.